Research
科研成果
Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity
Cui Yanhui, Wang Xueqin, Lu Caiyang, Ran Liling, Guo Zirui, Yao Jiayu, Yu Tian, Liu Xuanxi, Li Fang, Li Changqi, Meng Yingcai, Zhou Wenhu
Small-molecule PCSK9 inhibition enhances BBB amyloid-beta clearance and suppresses microglial inflammation in Alzheimer's disease models
Miao Jie, Wang Jing, Zhou Wenhu, Guo Junhong
Nanocluster-mediated co-delivery of silver ions and fluconazole enhances antifungal therapy for urinary tract infections via energy metabolism modulation
Li Qingnian, Zhang Ye, Zhu Jiaojiao, Xu Linyong, Wang Shengfeng, Yang Minghua, Zhou Wenhu
Liposomal nanocarriers in precision oncology: Advances and prospects
Li Yanhui, Zhou Wenhu
Aptamer-Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap
Al-Azzani Hamdi, Vithran Djandan Tadum Arthur, Batool Syeda Sundas, Alshabi Malek Mohammed Ali, Zhou Wenhu, Mao Xiaoqiang
A Monocyte-Targeted Nanoplatform for Phagocytosis Activation and Ferroptosis Inhibition in Intracerebral Hemorrhage
Li Qingnian, Wang Jing, Miao Jie, Liu Dexian, Xiong Wanying, Xiao Bo, Zhou Wenhu
Breaking the oncogene-immune suppression cycle through dual HER2 silencing and innate immune activation by biomineralized DNA nanocomplexes
Duan Yubei, Huang Jiaxin, Huang Tianping, Yang Kaige, Qi Liwen, Yu Baohua, Li Fanping, Yin Maosheng, Zhao Lei, Chai Zhenghua, Liang Weihua, Zhang Haijun, Fei Jing, Ding Jinsong, Luo Chenghua, Zhou Wenhu, Hu Jianming
Nanobody-based radiotracers in nuclear medicine: Advances, challenges, and future perspectives
Yao Ying, Tian Juan, Zhang Ran, Liu Ping, Gao Xiang, Zhou Wenhu, Luo Longlong
Dual-functional tea polyphenol-serotonin nanoparticles for integrated inflammation suppression and mucosal repair in inflammatory bowel disease
Tian Li, Huang Jiaxin, Xu Youwei, Zhao Panpan, Li Yankun, Wei Xiaomin, Li Mingdong, Jiang Shiyin, Huang Qianping, Xu Yi, Lu Caiyang, Ding Jinsong, Zhou Wenhu, Gao Xiang
Multifunctional selenium nanoplatforms for synergistic ferroptosis inhibition and immune microenvironment remodeling in oral mucositis
Ouyang Qin, Gao Runwei, Li Sisi, Liang Junhao, Li Pei, Zhou Wenhu
A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self-Polymerization
Hao Chen, Lina Guo, Jinsong Ding, Wenhu Zhou*, Yan Qi
Reversing the Negative Effect of Adenosine A1 Receptor-Targeted Immunometabolism Modulation on Melanoma by a Co-delivery Nanomedicine for Self-activation of anti-PD-L1 DNAzyme
Jia Guo, Peng Liu, Benliang Wei, Ying Peng, Jinsong Ding, Wenhu Zhou*
Multifunctional nanomedicine targeting the 'seed-and-soil' of hair follicles via simultaneous alleviation of oxidative stress and activation of autophagy for androgenetic alopecia therapy
Yuanzheng Chen, Qubo Zhu, Yanbin Zhou, Wenhu Zhou*, Yan Chen*
Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy
Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie*, Wenhu Zhou*, Shuang Zhao*
Enhanced Xanthium-Inspired ZnO for Precision Antibacterial Therapy and Regeneration of Infected Wounds
Jiaojiao Zhu, Tiao Wen, Yunxiao Ma, Qingya Zeng, Yilan Lin, Yutian Liu, Shanshan Chen, Qiang Wang*, Wenhu Zhou*
Smart Nanosilver Strikes Twice: Precision Bacteria Killing Meets Autophagy-Boosted Healing for Infected Wounds
Jiaojiao Zhu, Qingya Zeng, Yutian Liu, Yilan Lin, Ding Ma, Tiao Wen, Pei Li, Wenhu Zhou*
Biomimetic Hyaluronic Acid-Stabilized Zinc Oxide Nanoparticles: Selective Antibacterial Activity and Multi-Mechanistic Skin Repair for Acne Treatment
Jiaojiao Zhu, Tiao Wen, Yunxiao Ma, Qingya Zeng, Pei Li, Wenhu Zhou*
Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications
Qingya Zeng, Jiaojiao Zhu, Zongyun He, Hong Qin, Wenhu Zhou*, Fangqi Hua*, Jin Yang*
Transdermal Psoriasis Treatment Inspired by Tumor Microenvironment-Mediated Immunomodulation and Advanced by Exosomal Engineering
Jieru Yang, Jiaojiao Zhu, Shan Lu, Hong Qin, Wenhu Zhou*
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou*, Wenqun Li*, Songwen Chen*
A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy
Ying Yao, Yuanzheng Chen, Jie Fu, Jinsong Ding, Wenhu Zhou*, Xinyi Chen*, Xiuping Wan*
A 177Lu-nucleotide coordination polymer-incorporated thermosensitive hydrogel with anti-inflammatory and chondroprotective capabilities for osteoarthritis treatment
Peng Liu, Ming Zhou, Zhisheng Luo, Lu Hao, Jessica C. Hsu, Weibo Cai, Wenhu Zhou*, Shuo Hu*
A novel levodopa-carbidopa three-layer gastroretentive tablet for improving levodopa pharmacokinetics
Xiangcheng Zhao, Peng Yan, Hailong Zhang, Wenhu Zhou*, Jinsong Ding*
Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation
Cui Tang, Hui Wang, Lina Guo, Yimin Cui, Chan Zou, Jianming Hu, Hanyong Zhang, Guoping Yang*, Wenhu Zhou*
Bismuth/manganese-doped carbon dots in calcium phosphate matrix: Dynamic conformational nanoparticles enhancing tumor accumulation, deep penetration, and radiosensitivity
Jiahao Liu, Qingnian Li, Hanyu Tu, Jie Feng, Xiaofei Fan, Ze Mi, Hongpei Han, Xiaoqian Ma, Qi Liang, Zheng Zhang, Hongshuai Hou*, Pengfei Rong*, Wenhu Zhou*
Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload
Ying Peng, Peng Liu, Jinsong Ding, Wenhu Zhou*
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy
Lina Guo, Jinsong Ding, Wenhu Zhou*
G-quadruplex/Hemin DNAzyme-Functionalized Silver Nanoclusters with Synergistic Anti-Bacterial and Wound Healing Capabilities for Infected Wound Management
Jiaojiao Zhu, Tiao Wen, Shuangquan Qu, Qingnian Li, Biwu Liu, Wenhu Zhou*
Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor
Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou*
Structure Determination and 3D ED/MicroED-Guided Synthesis of a New (S)-Ibuprofen-L-phenylalanine Co-Crystal
Youwei Xu, Zhonghui Zheng, Qing Lin, Jiaxin Huang, Jinsong Ding, Wenhu Zhou*
Harnessing bacteria for tumor therapy: Current advances and challenges
Lina Guo, Jinsong Ding, Wenhu Zhou*
Recent progress of vaccines administration via microneedles for cancer immunotherapy
Yuanzheng Chen, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou
A Renal-Targeted Gene Delivery System Derived from Spermidine for Arginase-2 Silencing and Synergistic Attenuation of Drug-Induced Acute Kidney Injury
Xurui Gu, Kun Liu, Yixuan Deng, Bixiao Xiang, Lingyun Zhou, Wenjun Yin, Jiaxin Huang, Yingcai Meng, Dianke Li, Ruiman Que, Zhiyao Tang, Guangliang Zhou, Yifeng Wu, Yujie Huang, Wenhu Zhou*, Xiaocong Zuo*
Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases
Xueming Xu, Yuanfeng Han, Jiali Deng, Shengfeng Wang, Shijie Zhuo, Kai Zhao*, Wenhu Zhou*
Activable Photodynamic DNA Probe with an "AND" Logic Gate for Precision Skin Cancer Therapy
Jiaojiao Zhu, Lanyuan Peng, Shah Jehan, Haiyang Wang, Xiang Chen, Shuang Zhao, Wenhu Zhou*
CpG and Rutin Co-Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition
Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*
Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression
Hui Wang, Cui Tang, Yuxia Xiang, Chan Zou, Jianming Hu, Guoping Yang*, Wenhu Zhou*
Tumor Cell-Targeting and Tumor Microenvironment-Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer
Ying Wang, Yiyan Xu, Jiayu Song, Xueting Liu, Sijia Liu, Nan Yang, Le Wang, Yujie Liu, Yiwei Zhao, Wenhu Zhou*, Yunyan Zhang*
Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy
Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou*, Yong Li*, Wenhu Zhou*
A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy
Ming Zhou, Xiaoqin Yin, Bei Chen, Shuo Hu*, Wenhu Zhou*
Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy
Shan Lu, Ze Mi, Peng Liu, Jinsong Ding, Yiran Ma, Jieru Yang*, Pengfei Rong*, Wenhu Zhou*
An iron-containing nanomedicine for inducing deep tumor penetration and synergistic ferroptosis in enhanced pancreatic cancer therapy
Aiping Huang, Qingnian Li, Xinyi Shi, Junyi Gao, Yiran Ma, Jinsong Ding, Surong Hua*, Wenhu Zhou*
Breaking Down Barriers in Drug Delivery by Stromal Remodeling Approaches in Pancreatic Cancer
Ying Zhou, Yunxiao Ma, Jianwei Sheng, Yiran Ma, Jinsong Ding*, Wenhu Zhou*
Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition
Yujie Fan, Yangqin Ou, Ting Xiao, Ziye Wei, LiLing Zhu, Chenghao Zhu, Yiran Ma, Shuangquan Qu*, Wenhu Zhou*
Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy
Jiahao Liu, Peng Liu, Junhong Duan, Qiongxuan Xie, Jie Feng, Hongpei Tan, Ze Mi, Ying Li, Yunjie Liao, Pengfei Rong*, Wenhu Zhou*, Xiang Gao*
Mitigation of Cisplatin-Induced Nephrotoxicity and Augmentation of Anticancer Potency via Tea Polyphenol Nanoparticles'' Codelivery of siRNA from CRISPR/Cas9 Screened Targets
Lingjiao Li, Chengyao Feng, Wenchao Zhang, Lin Qi, Binfeng Liu, Hua Wang, Chenbei Li, Zhihong Li, Chao Tu*, Wenhu Zhou*
Harnessing Tumor Cell-Derived Exosomes for Immune Rejection Management in Corneal Transplantation
Jieru Yang, Huanmin Kang, Yingyi Liu, Yan He*, Wenhu Zhou*
Co-Delivery of aPD-L1 and CD73 Inhibitor Using Calcium Phosphate Nanoparticles for Enhanced Melanoma Immunotherapy with Reduced Toxicity
Peng Liu, Jia Guo, Zuozhong Xie, Yusheng Pan, Benliang Wei, Ying Peng, Shuo Hu, Jinsong Ding, Xiang Chen*, Juan Su*, Hong Liu*, Wenhu Zhou*
Copper carbonate nanoparticles as an effective biomineralized carrier to load macromolecular drugs for multimodal therapy
Liping Dong, Jinsong Ding, Lemei Zhu, Yujun Liu, Xiang Gao*, Wenhu Zhou*
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
Hui Zhang, Laifa Wang, Yongping Yang, Chuanhai Cai, Xueqin Wang, Ling Deng, Binsheng He, Wenhu Zhou*, Yanhui Cui*
Balance Cell Apoptosis and Pyroptosis of Caspase-3-Activating Chemotherapy for Better Antitumor Therapy
Lingjiao Li, Shengmei Wang, Wenhu Zhou*
Macrophages-Regulating Nanomedicines for Sepsis Therapy
Jiali Deng, Rui Wang, Jinsong Ding*, Wenhu Zhou*
Mn-based cGAS-STING activation for tumor therapy
Aiping Huang, Wenhu Zhou*
Targeting nano-regulator based on metal-organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer
Shu Huang, Jun Yuan, Yong Xie, Kai Qing, Zeya Shi, Guanyu Chen, Jie Gao, Haoxiang Tan, Wenhu Zhou*
Poly-thymine DNA templated MnO2 biomineralization as a high-affinity anchoring enabling tumor targeting delivery
Yingcai Meng, Jiaxin Huang, Jinsong Ding, Bohua Yan, Yong Li*, Xiang Gao*, Wenhu Zhou*
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats
Hui Zhang, Laifa Wang, Bi Zhu, Yongping Yang, Chuanhai Cai, Xueqin Wang, Ling Deng, Binsheng He, Yanhui Cui*, Wenhu Zhou*
Bacterial Drug Delivery Systems for Cancer Therapy: "Why" and "How"
Xiangcheng Zhao, Nuli Xie, Hailong Zhang, Wenhu Zhou*, Jinsong Ding*
CpG Conjugated Silver Nanoparticle as Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Re-polarization for Atherosclerosis Therapy
Cui Tang, Hui Wang, Lina Guo, Chan Zou, Jianming Hu, Hanyong Zhang, Wenhu Zhou*, Guoping Yang*
Salmonella-Mediated Blood-Brain Barrier Penetration, Tumor Homing and Tumor Microenvironment Regulation for Enhanced Chemo/Bacterial Glioma Therapy
Ze Mi, Qing Yao, Yan Qi, Jinhai Zheng, Jiahao Liu, Zhenguo Liu, Wenhu Zhou*, Pengfei Rong*
Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy
Jiaojiao Zhu, Man Guo, Yanhui Cui, Yingcai Meng, Jinsong Ding, Wenbin Zeng, Wenhu Zhou*
Study on the Mechanism of Astragalus Polysaccharide in Treating Pulmonary Fibrosis Based on "Drug-Target-Pathway" Network
Pingping Bing, Wenhu Zhou*, Songwen Tan*
Combinatorial effect of thymoquinone with chemo agents for tumor therapy
Shah Jehan, Jiaxin Huang, Umar Farooq, Irum Basheer, Wenhu Zhou*
Macrophage-targeted nanomedicine for chronic diseases immunotherapy
Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding*, Wenhu Zhou*
Self-oxygenation Mesoporous MnO2 Nanoparticles with Ultra-High Drug Loading Capacity for targeted Arteriosclerosis Therapy
Weidong Sun, Yiyan Xu, Ye Yao, Jie Yue, Zhen Wu, Haocheng Li, Guanghui Shen, Yan Liao, Haiyang Wang*, Wenhu Zhou*
Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer''s Disease
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou*, Jianbin Tong*
Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy
Mengzhen Yu, Yanwen Zhang, Meirong Fang, Shah Jehan*, Wenhu Zhou*
Polyserotonin as a Versatile Coating with pH-responsive Degradation for Anti-tumor Therapy
Yingcai Meng, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou*
Non-cytotoxic Nanoparticles Re-educating Macrophages Achieving both Innate and Adaptive Immune Responses for Tumor Therapy
Shengmei Wang, Xuanjun Liu, Minghua Yang, Linqi Ouyang, Jinsong Ding, Shengfeng Wang*, Wenhu Zhou*
Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis
Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Junyu Li*, Wenhu Zhou*
Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Blocks Pyroptosis in Endotoxin-Induced Sepsis
Yuan Chen, Ruiheng Luo, Jing Li, Shengfeng Wang, Jinsong Ding, Kai Zhao*, Ben Lu*, Wenhu Zhou*
Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery
Jiaojiao Zhu, Ruimin Chang, Benliang Wei, Yao Fu, Xiang Chen*, Hong Liu*, Wenhu Zhou*
Vascular Bursts-Mediated Tumor Accumulation and Deep Penetration of Spherical Nucleic Acids for Synergistic Radio-Immunotherapy
Jiahao Liu, Lina Guo, Ze Mi, Liu Zhenguo, Pengfei Rong*, Wenhu Zhou*
Anti-PD-L1 DNAzyme Loaded Photothermal Mn2+/Fe3+ Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy
Peng Liu, Xinyi Shi, Ying Peng, Jianming Hu, Jinsong Ding, Wenhu Zhou*
Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy
Lina Guo, Shenghui Zhong, Peng Liu, Man Guo, Jinsong Ding, Wenhu Zhou*
Pure DNA scaffolded Drug Delivery Systems for Cancer Therapy
Hanane Aliouat, Ying Peng, Zoya Waseem, Shengfeng Wang, Wenhu Zhou*
Fenton Metal Nanomedicines for Imaging-guided Combinatorial Chemodynamic Therapy against Cancer
Peng Liu, Ying Peng, Jinsong Ding, Wenhu Zhou*
Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery
Yang Zeng, Haiyan Zhou, Jinsong Ding, Wenhu Zhou*
Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization
Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding, Wenhu Zhou*
Trojan Horse Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety
Ze Mi, Lina Guo, Peng Liu, Yan Qi, Zhichao Feng, Jiahao Liu, Jinsong Ding, Wenhu Zhou*, Pengfei Rong*
Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia
Shengmei Wang, Xuanjun Liu, Shengfeng Wang, Linqi Ouyang, Hui Li, Jinsong Ding, Guiming Deng*, Wenhu Zhou*
Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells
Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu
Metal Sensing by DNA
Wenhu Zhou, Runjhun Saran, Juewen Liu*
Theranostic DNAzymes
Wenhu Zhou, Jinsong Ding, Juewen Liu*